blue lump under skin

Blue Nevus: Identification, Removal, and MoreWarning: The NCBI website requires JavaScript to operate. Multiple broad-bread blue nodules: a clinical-pathological caseAbstractLomangiomas are a variant of benign glome tumors; glomus tumors are benign neoplastic glomus proliferations of the glomus body, which consists of perivascular smooth muscle cells. This forms arteriovenous anastomosis that plays an important role in the vascular regulation of skin temperature. The aim of this article is to describe 2 cases of hereditary glomangiomas. Case report The first case is a 29-year-old female who presented a 2-year history of multiple blue nodules especially in her trunk and extremities, ranging from 0.5–2.5 cm in size. Although some of the injuries had been present since he was 5 years old, his accelerated growth during the past year had caused concern. There were no other systemic features present. His mother also reported 2-3 similar injuries, which had been developed during adolescence, in her senior members but no research had been conducted in the past. No other family member was affected. Several soft and partially compressible nontender blue, nodules and multifocal lesions that ranged from 0.5 to 2.5 cm in diameter were observed at the back, flanks, thighs, upper arms, palms and soles (fig.). Most of the injuries were discreet but there were some that were collapsing. Blue nodules to the palm of the hand, b on the elbow, and c on the foot. The second case is a 14-year-old female who presented several subcutaneous nodules in the leg and trunk, some of which were painful. His younger sister, 6 years old, was observed to have similar injuries on her feet (fig.). His 49-year-old mother had similar injuries to her trunk, especially on her back and shoulder. Precision biopsy taken from both cases 1 (nodules in its lower back) and case 2 (right page) showed an unencapsulated intradermal tumor composed of thin-walled vascular channels aligned by endothelial cells. These were surrounded by irregular layers of cuboidal cells, according to cells similar to glomus (fig.), which stained positively for smooth muscle actin in immunohistochemical (fig.). The retention for S-100 was negative. The diagnosis was hereditary glomangiomas in both cases. a Folded and dilated vascular canals of thin intradermal walls (haematoxylin and eosine, original magnification ×50). b Intradermal vascular canals lined by benign flat endothelial cells and round monomorphic cells with large glome and slightly eosinophilic cytoplasm (haematoxylin and eosine, original magnification ×350). DiscussionLomangiomas is a variant of benign glome tumors. Glomus tumors are benign neoplastic proliferations of the glomus body, which consists of lipid perivascular muscle cells and arteriovenous anastomous forms, which play an important role in the vascular regulation of the skin temperature []. The occurrence of malignant glomus tumors is extremely rare []. Glomus tumors are typically solitary benign lesions. They present in young individuals such as small papules or nodules and are blue or blue-purple in appearance. The most affected sites are distal limbs, such as nail bed or palm. Glomus tumors are typically painful and tender to touch, especially in response to temperature or pressure changes. Historically, there are solid glomus cell leaves around small blood vessels [, ]. Lomangiomas differ clinically from glomus tumors in which they occur in childhood and adolescence, do not have a predilection for the subungal region, and are often multifocal. They can rarely be congenital. In addition, they are often painless even though they can be tender to play. They are usually multiple, soft, blue red nodules, but may appear as pink to tile lesions. They are often widespread, and can join to become larger plates. They tend to be thicker and bluer with age. The histopathology of glomangiomas differs from the glomus tumors in which there are dilated venous channels, which appear to be venous malformations that positively stain for α-smooth muscle actin. They are less circumscribed than glomus tumors []. Most glomangiomas are manifested sporadicly; however, reports have been submitted showing dominant autosomal inheritance patterns. Our cases, both having a strong familiarity with many affected members in different generations, seem to be family-type, with dominant heritage. It is believed that chromosome 1p21–p22 is involved, and it has been suggested that this results in the loss of the function of glomulin protein, which is considered important for the differentiation of smooth muscle cells [, ]. Due to the benign, painless course, often no treatment is required. However, surgical excision can be used for symptomatic lesions. The excision can be more difficult for multiple glomus tumors due to its low circumscription and the large number of lesions. For these cases, there are a range of possible treatments, including sclerotherapy, electron radiation, argon and CO2 laser or observation of asymptomatic lesions. The prognosis for excise glome tumors is very good, with a low rate of recurrence []. ReferencesFormats: Share , 8600 Rockville Pike, Bethesda MD, 20894 USA

How to identify and treat a Blue Nevus What is a blue nevus? Moles, also called nevi, may appear on your skin in a variety of shapes, sizes and colors. Some kind of mole is the blue nevu. This mole gets its name from its blue color. Although these topos may seem unusual, they are generally benign and not cause concern. But like any mole, you'll want to keep an eye on it for changes over time. Keep reading to learn more. Moles can appear in all kinds of tones, not only the typical brown or tanned variety that you could expect. These moles appear blue because the pigmented skin patch that creates them is set lower on the skin than the topos and the brown toes. The shadow of a blue nevus can vary from light to dark blue. Other common features are: It is possible to have another type of blue nevus beyond the common variety. One of them is the cellular blue nevu. This guy: In cases, your blue nevu can be evil. Cancerous nevi may appear as a common or cellular blue nevu but develop at a later age and may start to look like ulcers. They may also have a more nodular or similar form to the plate. The blue nevi can appear in many places in the body and are usually isolated. This means you probably won't see more than one nevus in a given area. Some places you can find a blue nevu in your body include your: It is not clear what causes blue nevi. In young children and adults and in women. Evil blue nevi. The men of their 40 years can have one for this guy. The blue nevi may appear at any age. You may have one at birth or may develop later in your life. It's not unusual to have a blue nevus. Most people have between, and those who have skin topos just like others. You can even notice that the moles change color, tone or size as it grows from childhood. The methods that develop in adulthood can be of concern. If you have a blue nevus or other topo appears after 30 years, consult your doctor. It can be a sign of skin cancer like . Changes to blue nevi or other topos can also be a matter of concern. Keep an eye on any abrupt or subtle changes in your skin and the polka dots will ensure that you detect early signs of skin cancer. You should flag blue nevi, along with other topos, when: If you notice any of these changes, consult your doctor for an evaluation. Although your doctor may be able to diagnose blue nevus immediately when looking at it, they may recommend a . This may determine if the mole is malignant. A blue nevus is usually not problematic. You can have a benign blue nevu on your skin for your entire life. The only time your doctor will recommend removal is if the mole is evil. You can also talk to your doctor about removal if the mole is causing discomfort. For example, if you rub against the skin or cause another irritation. Your doctor may chop by cutting or shaving it with a . You may receive a local anesthesia and may need points. The skin surrounding the removed mole will heal over time. If the blue nevus reappear after removal, contact your doctor. This could be a sign of skin cancer. Finding a blue topo on the skin is usually not cause of alarm. These moles are typically benign. But if the mole appears later in life, or if an earlier mole is changing over time, you should see your doctor. You can check the malignity and advise you in your next steps. Last medical review on September 14, 2017 related stories Read this next series of words

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